For an oocyte being ready for fertilization and progress into an embryo, the right list of genes really should be turned on. Namekawa suspected that this pre-programming from the oocyte genome comes about in many levels — the very first one starting across the time a female is born. He thought that chromatin remodeling proteins did much of the work, by shifting spools all over.
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Munakata and Namekawa will Assess mice with typical and mutated variations from the chromatin remodeler. As the mice increase and mature, they are going to notice whether or not the existence or absence of this protein triggers variations within the arrangement of DNA spools inside the animals’ oocytes. And they will check no matter if this, in turn, alters the sample of gene expression eventually.
Each consists of a mass of thread-like DNA — akin to four hundred miles of yarn. To help keep it from devolving into a tangle, the DNA is wrapped about a series of protein spools, called nucleosomes.
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